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Clinical Research Library | AMORYN

Click on one of the studies below to view the text of the article, or click here to close this window and exit the Clinical Research Library. 

Clinical trials with hypericum extracts in patients with depression--results, comparisons, conclusions for therapy with antidepressant drugs. 
Schulz V. Phytomedicine, 2002 Jul;9(5):468-74. 

Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine. (Full Text) 
Szegedi A, Kohnen R, Dienel A, Kieser M. British Medical Journal, 2005 Apr 2; 330(7494):759. 

A double-blind, randomized trial of St. John's wort, fluoxetine, and placebo in major depressive disorder. 
Fava M, Alpert J, Nierenberg AA, Mischoulon D, et al. Journal of Clinical Psychopharmacology, 2005 Oct; 25(5):441-7. 

Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomized, placebo-controlled trials. 
Kasper S, Dienel A. Psychopharmacology (Berl), 2002 Nov;164(3):301-8. 

Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial. 
Lecrubier Y, Clerc G, Didi R, Kieser M. American Journal of Psychiatry, 2002 Aug;159(8):1361-6. 

Efficacy and tolerability of hypericum extract STW3 in long-term treatment with a once-daily dosage in comparison with sertraline. 
Gastpar M, Singer A, Zeller K. Pharmacopsychiatry, 2005 Mar;38(2):78-86. 

Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study. 
Brenner R, Azbel V, Madhusoodanan S, Pawlowska M. Clinical Therapeutics, 2000 Apr;22(4):411-9. 

Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort. 
Friede M, Henneicke von Zepelin HH, Freudenstein J. Pharmacopsychiatry, 2001 Jul;34 Suppl 1:S38-41. 

Safety of St. John's wort extract compared to synthetic antidepressants. 
Schulz, V. Phytomedicine, 13(3):199-204. 

Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs: A reanalysis of data from controlled clinical trials in acute major depression. 
Kasper, S., Gastpar, M., Moller, H.J., Muller, W.E., Volz, H.P., Dienel, A. & Kieser, M. International Clinical Psychopharmacology, 2010 25(4):204-13. 

Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. 
Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malstrom C, Panossian A. Nordic Journal of Psychiatry. 2007; 61(5):343-348. 

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